Genre: Comedy/Crime
Director: David Dobkin
Based on the novel by Carl Hiaasen
Cast: Vince Vaughn, Billy Bob Thornton, Kevin Durand, Jessica Alba, Will Arnett, Christina Hendricks, Benjamin Bratt, Heather Graham, David Koechner, Amber Valletta
Plot: Dr. Rudy Graveline, M.D. (Billy Bob Thornton), the director of the prestigious "Whispering Palms" Surgery Center in Bal Harbour, Florida, is in fact a complete fraud. He has built his reputation through social connections and by taking credit for the work of his more-competent associates. On the rare occasions when Graveline himself performs surgery, the results are inevitably disastrous. He has weathered numerous malpractice complaints and investigations by the state, through bribery and intimidation.
However, there is at least one mistake in Rudy's past that no amount of money or prestige could fix, were it ever to come to light: the accidental killing of a college coed named Victoria Barletta, during a botched nose job. So, when Rudy's former surgical nurse, Maggie Gonzalez (Jessica Alba), tells Rudy that Mick Stranahan (Vince Vaughn), a retired investigator for the Florida State Attorney's office, is looking into Victoria's disappearance again, Rudy decides to have Stranahan killed. In reality, Maggie is the whistleblower. After promising to repeat the true story on live television, for the sensationalist talk show "In Your Face!", Maggie has pointed to Stranahan to misdirect Rudy.
Stranahan is eating breakfast on his house in Stiltsville, in Biscayne Bay, when a hit man from the mob appears at his front door with a gun. Mick ambushes the man, impaling him through the chest with the sword of a stuffed marlin head, then pushes the body out to sea and decides to find out who wants him dead. He meets the obnoxious host of "In Your Face!", Reynaldo Flemm (Will Arnett), and his producer, Christina Marks (Christina Hendricks), who have come to Miami looking for Maggie after she left New York City without warning. Mick has no time for Reynaldo, but finds himself attracted to Christina.
After the mob hitman's failure, Graveline hires a disfigured felon nicknamed "Chemo" (Kevin Durand) who agrees to kill Stranahan in exchange for a discount on his dermabrasion treatments.
Chemo locates Stranahan the same way that Christina did: through his vengeful ex-wife, Chloe (Heather Graham). When Chemo says he's out to "get" Stranahan, she shows him the way to the stilt house, and eagerly comes along to watch. But when she realizes that Chemo means to kill Stranahan, not just scare him, she objects, since she is still receiving alimony. They begin to argue, and she makes the mistake of insulting his face, to which he responds by drowning her in the Bay. Fortunately for Mick, Chloe's directions were wrong, and Chemo burns down an abandoned stilt house instead of Mick's.
The next day, homicide detective Al Garcia (Benjamin Bratt) visits Stranahan's stilt house to inform him that Chloe's body has been found, and he's the prime suspect in her murder. When Stranahan tells Garcia that someone is trying to kill him, Garcia advise him to lie low. Instead of doing so, Mick visits Dr. Graveline outside his clinic, advises him in the strongest terms to abandon his plans to murder Mick, and emphasizes his point by blowing up the doctor's Jaguar.
Mick returns to his stilt house, where Christina visits him. She says that she interviewed Mick's old partner, Timmy Gavigan, at the hospital. Before Timmy died, he told her that he'd remembered a detail from the Barletta case: Graveline's brother, George (David Koechner), is a tree trimmer by profession. She isn't sure what that means, but Stranahan is: most trimmers use a wood chipper, an ideal device for disposing of a body in a hurry.
Chemo appears on the house with a submachine gun, having been told by Graveline that Mick is still alive. In the ensuing shootout, Mick is wounded in the shoulder, and Chemo dives off the house to avoid a shotgun blast. Swimming around the ocean, his hand is bitten off by a barracuda. Making his way back to Graveline, he opts to attach a portable weed whacker to the stump of his arm instead of a conventional prosthesis.
Graveline gives Chemo another job: to go to New York City and eliminate Maggie Gonzalez. But when Chemo finds her in New York, she mentions being a nurse by training, and tells him the truth about Rudy's incompetence. Mortified that he has entrusted his face to such a dangerous hack, Chemo decides to form a partnership with Maggie, to blackmail Rudy with the knowledge about Victoria Barletta's death. Maggie has created a videotaped confession for security, but Stranahan and Christina have gotten hold of a copy.
Returning to Miami, Stranahan delivers the video to Al Garcia, before surviving another murder attempt: this time, a pair of corrupt Miami detectives (former cronies of a corrupt judge that Stranahan killed in self-defense), are hired by one of Rudy's buddies, a corrupt county commissioner, to kill Stranahan. Yet again, Stranahan outfoxes them and lures them into a fatal booby trap. He then confronts George Graveline, the tree trimmer, who tries to kill Stranahan rather than talk, and is shot dead by Al Garcia.
Chemo and Maggie kidnap Christina, holding her hostage in exchange for Mick's copy of the videotape. Meanwhile, Reynaldo Flemm, jealous of Christina's growing attraction to Mick, comes up with his own plan to break the Barletta case: he schedules a nose job and abdominoplasty with Rudy, planning to conduct an ambush interview once the nose job is done. His "brilliant" plan quickly goes awry when Rudy announces that he plans to do the abdominoplasty first, and puts Reynaldo under general anesthesia. When Reynaldo's cameraman bursts into the operating room to start the interview, Rudy panics and accidentally stabs the unconscious Reynaldo through the heart with a liposuction cannula.
Fleeing the clinic with Reynaldo's body, Rudy calls George, only to be told that he is dead. Now realizing that he has no option left except to flee the country, Rudy returns home, only to find he can't go: his girlfriend, Hollywood actress Heather Chappell (Amber Valletta), has been kidnapped by Stranahan. Realizing they'll never get paid until Stranahan is no longer a threat to Rudy, Chemo and Maggie join Rudy to confront Stranahan at the stilt house, taking Christina with them.
During the confrontation, Stranahan knocks out Chemo and Rudy, and sends Christina, Maggie and Heather back to the mainland. Stranahan then attempts to "jog" Rudy's memory of Victoria Barletta's death by "recreating" the circumstances of the botched nose job, with Rudy as the "patient." Scared, Rudy confesses: he killed Vicki (purely by accident), then got George to get rid of the body. He also confesses to hiring Chemo to kill Stranahan; Chemo is so alarmed (or embarrassed) at Stranahan learning that Chemo agreed to kill him in exchange for a discount on surgery, that he kills Graveline. Stranahan ties Chemo up, calls the police, and swims away. Garcia arrives, and Chemo is arrested.
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